hydrochlorothiazide 25 mg scored tablet
thiazide diuretic used as anti hypertensive drug.
thiazide diuretic act mainly on the distal renal tubule inhibiting Na Cl reabsorption and promoting ca reabsorption
In hypertension as monotherapy and in combination with other anti hypertensives( eg. b blocker,vasodilators, ca antagonists, ACE inhibitors, reserpine)
Heart Failure
Edema due to heart failure, or mild to moderate kidney falure or liver failure
Nephrogenic diabetes insipidus or recurrent ca oxalate calculi
the dosage depends on the clinical picture and patient's response where a single daily dose is prescribed this is the best taken in the morning with breakfast.
in the case of long term therapy the lowest dose compatible with optimum effect should be given particularly in elderly patients
hypertension
adults:the initial dose is generally 25-50 mg daily taken in the morning in 2 doses. for long term treatment 12.5-25 mg every morning is usually enough if blood pressure reduction is not adequate, co medication with another antihypertnsive is recommended. this way the dosage of each substance can often be kept lower.
heart failure and edema
adults:the initial dose is25-75 mn daily given in 1-2 doses in isolated cases the initial dosage can be increases but giving more than 100 mg seldom makes the treatment more effective.
if the effect is inadequate positive inotropic substances and vasodilators should be used
once the patient has begun to respond satisfactory 25 mg daily or possibly every other day is usually adequate for maintainance therapy.
the mean dosage in children is usually 2mg/kg daily depending on clinically picture.
nephrogenic diabetes insipidus
adults: the initial dose is 100 mg daily given in 2-4 single doses later the dosage may be reduced
idiopathic hypercalciuria and prevention of recurrent ca oxalate calculi
adults: 25-50 mg twice daily
anuria, severe renal and hepatic failure
hypersenitivity to hydrochlorothizide and other sulphonamide derivative, refractory hypokalemia, hyponatremia and hypercalinemia( history of gout or uric acid calculi) creatinine clearance < 30 ml/ min
conditios asociated with increased potassium loss
stored in dry place at a temprature not exceeding 30 c
box contains 30 tablet: 6 EGP
